Evidence synthesis Stronger human signal 3 randomized trials, 1,094 participants
Adjuvant PSK after colorectal cancer surgery: meta-analysis
A pooled analysis of three Japanese randomized trials reported better five-year overall and disease-free survival when PSK was added to postoperative chemotherapy. The finding is specific to PSK as an adjunct in the studied regimens.
- What was studied
- PSK added to postoperative fluoropyrimidine chemotherapy
- Setting
- Studied with standard care
- Why it ranks here
- The analysis pooled randomized evidence and measured clinical outcomes, while remaining limited to an older, specific treatment context.
Limits and cautions
- The chemotherapy regimens and clinical era differ from many current standards.
- The evidence concerns a standardized PSK product rather than generic Turkey Tail supplements.
- The analysis studied postoperative adjunct use, not stand-alone treatment.
PSK is not FDA-approved in the United States as a cancer treatment.